Multifunnel Landscape of the Fold-Switching Protein RfaH-CTD.
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ABSTRACT:
SUBMITTER: Bernhardt NA
PROVIDER: S-EPMC5823028 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Multifunnel Landscape of the Fold-Switching Protein RfaH-CTD.
Bernhardt Nathan A NA Hansmann Ulrich H E UHE
The journal of physical chemistry. B 20180124 5
Proteins such as the transcription factor RfaH can change biological function by switching between distinct three-dimensional folds. RfaH regulates transcription if the C-terminal domain folds into a double helix bundle and promotes translation when this domain assumes a β-barrel form. This fold-switch has been also observed for the isolated C-terminal domain, dubbed by us as RfaH-C-terminal domain (RfaH-CTD), and is studied here with a variant of the replica-exchange-with-tunneling approach rec ...[more]
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