Ontology highlight
ABSTRACT:
SUBMITTER: Zuber PK
PROVIDER: S-EPMC6370827 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Zuber Philipp Konrad PK Schweimer Kristian K Rösch Paul P Artsimovitch Irina I Knauer Stefan H SH
Nature communications 20190211 1
RfaH, member of the NusG/Spt5 family, activates virulence genes in Gram-negative pathogens. RfaH exists in two states, with its C-terminal domain (CTD) folded either as α-helical hairpin or β-barrel. In free RfaH, the α-helical CTD interacts with, and masks the RNA polymerase binding site on, the N-terminal domain, autoinhibiting RfaH and restricting its recruitment to opsDNA sequences. Upon activation, the domains separate and the CTD refolds into the β-barrel, which recruits a ribosome, activa ...[more]