Cancer Risk in Families Fulfilling the Amsterdam Criteria for Lynch Syndrome.

ABSTRACT:

Importance

The data describing cancer risks associated with Lynch syndrome are variable.

Objectives

To quantify the prevalence of families that fulfill the Amsterdam I or II criteria for Lynch syndrome in the Utah population and investigate the risk of colonic and extracolonic cancers in family members and their relatives.

Design, setting, and participants

In a population-based study, 202 families with Amsterdam I and II criteria–positive pedigrees in the Utah Population Database were identified. Of these, all cancer diagnoses in members of families with Amsterdam criteria and their first-degree, second-degree, and first-cousin relatives were located through linkage to the Utah Cancer Registry. The study was conducted from May 1 to June 30, 2016.

Main outcomes and

SUBMITTER: Samadder NJ 

PROVIDER: S-EPMC5824265 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature