Ontology highlight
ABSTRACT:
SUBMITTER: Dhahbi JM
PROVIDER: S-EPMC5824904 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Dhahbi Joseph M JM Atamna Hani H Selth Luke A LA
Biomarkers in cancer 20180220
Extracellular RNAs are gaining clinical interest as biofluid-based noninvasive markers for diseases, especially cancer. In particular, derivatives of transfer RNA (tRNA) are emerging as a new class of small-noncoding RNAs with high biomarker potential. We and others previously reported alterations in serum levels of specific tRNA halves in disease states including cancer. Here, we explored seminal fluid for tRNA halves as potential markers of prostate cancer. We found that 5' tRNA halves are abu ...[more]