On the Viability of Diffusion MRI-Based Microstructural Biomarkers in Ischemic Stroke.

ABSTRACT: Recent tract-based analyses provided evidence for the exploitability of 3D-SHORE microstructural descriptors derived from diffusion MRI (dMRI) in revealing white matter (WM) plasticity. In this work, we focused on the main open issues left: (1) the comparative analysis with respect to classical tensor-derived indices, i.e., Fractional Anisotropy (FA) and Mean Diffusivity (MD); and (2) the ability to detect plasticity processes in gray matter (GM). Although signal modeling in GM is still largely unexplored, we investigated their sensibility to stroke-induced microstructural modifications occurring in the contralateral hemisphere. A more complete picture could provide hints for investigating the interplay of GM and WM modulations. Ten stroke patients and ten age/gender-matched healthy contro

SUBMITTER: Boscolo Galazzo I 

PROVIDER: S-EPMC5826355 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature