Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity.
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ABSTRACT:
SUBMITTER: Jensen IJ
PROVIDER: S-EPMC5826615 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity.
Jensen Isaac J IJ Sjaastad Frances V FV Griffith Thomas S TS Badovinac Vladimir P VP
Journal of immunology (Baltimore, Md. : 1950) 20180301 5
Sepsis results in a deluge of pro- and anti-inflammatory cytokines, leading to lymphopenia and chronic immunoparalysis. Sepsis-induced long-lasting immunoparalysis is defined, in part, by impaired CD4 and CD8 αβ T cell responses in the postseptic environment. The dysfunction in T cell immunity affects naive, effector, and memory T cells and is not restricted to classical αβ T cells. Although sepsis-induced severe and transient lymphopenia is a contributory factor to diminished T cell immunity, T ...[more]
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