Ontology highlight
ABSTRACT:
SUBMITTER: Hughes AJ
PROVIDER: S-EPMC5826757 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Hughes Alex J AJ Miyazaki Hikaru H Coyle Maxwell C MC Zhang Jesse J Laurie Matthew T MT Chu Daniel D Vavrušová Zuzana Z Schneider Richard A RA Klein Ophir D OD Gartner Zev J ZJ
Developmental cell 20171228 2
Many tissues fold into complex shapes during development. Controlling this process in vitro would represent an important advance for tissue engineering. We use embryonic tissue explants, finite element modeling, and 3D cell-patterning techniques to show that mechanical compaction of the extracellular matrix during mesenchymal condensation is sufficient to drive tissue folding along programmed trajectories. The process requires cell contractility, generates strains at tissue interfaces, and cause ...[more]