Ontology highlight
ABSTRACT:
SUBMITTER: Luo J
PROVIDER: S-EPMC7021512 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Luo Jiesi J Qin Lingfeng L Zhao Liping L Gui Liqiong L Ellis Matthew W MW Huang Yan Y Kural Mehmet H MH Clark J Alexander JA Ono Shun S Wang Juan J Yuan Yifan Y Zhang Shang-Min SM Cong Xiaoqiang X Li Guangxin G Riaz Muhammad M Lopez Colleen C Hotta Akitsu A Campbell Stuart S Tellides George G Dardik Alan A Niklason Laura E LE Qyang Yibing Y
Cell stem cell 20200116 2
Vascular smooth muscle cells (VSMCs) can be derived in large numbers from human induced pluripotent stem cells (hiPSCs) for producing tissue-engineered vascular grafts (TEVGs). However, hiPSC-derived TEVGs are hampered by low mechanical strength and significant radial dilation after implantation. Here, we report generation of hiPSC-derived TEVGs with mechanical strength comparable to native vessels used in arterial bypass grafts by utilizing biodegradable scaffolds, incremental pulsatile stretch ...[more]