Ontology highlight
ABSTRACT:
SUBMITTER: Huffman AP
PROVIDER: S-EPMC5826857 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Huffman Austin P AP Richman Lee P LP Crisalli Lisa L Ganetsky Alex A Porter David L DL Vonderheide Robert H RH Reshef Ran R
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20171020 3
Blocking lymphocyte trafficking after allogeneic hematopoietic stem cell transplantation is a promising strategy to prevent graft-versus-host disease (GVHD) while preserving the graft-versus-tumor response. Maraviroc, a CCR5 antagonist, has shown promise in clinical trials, presumably by disrupting the migration of effector cells to GVHD target organs. We describe a phosphoflow assay to quantify CCR5 blockade during treatment with maraviroc and used it to evaluate 28 patients in a phase II study ...[more]