Ontology highlight
ABSTRACT:
SUBMITTER: Rider MA
PROVIDER: S-EPMC5826876 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Rider Mark A MA Cheerathodi Mujeeb R MR Hurwitz Stephanie N SN Nkosi Dingani D Howell Lauren A LA Tremblay Deanna C DC Liu Xia X Zhu Fanxiu F Meckes David G DG
Virology 20180109
Epstein-Barr virus LMP1 is an oncoprotein required for immortalizing B lymphocytes and also plays important roles in transforming non-lymphoid tissue. The discovery of LMP1 protein interactions will likely generate targets to treat EBV-associated cancers. Here, we define the broader LMP1 interactome using the recently developed BioID method. Combined with mass spectrometry, we identified over 1000 proteins across seven independent experiments with direct or indirect relationships to LMP1. Pathwa ...[more]