Ontology highlight
ABSTRACT:
SUBMITTER: Lin S
PROVIDER: S-EPMC5827972 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Lin Shixian S Yang Xiaoyu X Jia Shang S Weeks Amy M AM Hornsby Michael M Lee Peter S PS Nichiporuk Rita V RV Iavarone Anthony T AT Wells James A JA Toste F Dean FD Chang Christopher J CJ
Science (New York, N.Y.) 20170201 6325
Cysteine can be specifically functionalized by a myriad of acid-base conjugation strategies for applications ranging from probing protein function to antibody-drug conjugates and proteomics. In contrast, selective ligation to the other sulfur-containing amino acid, methionine, has been precluded by its intrinsically weaker nucleophilicity. Here, we report a strategy for chemoselective methionine bioconjugation through redox reactivity, using oxaziridine-based reagents to achieve highly selective ...[more]