Ontology highlight
ABSTRACT:
SUBMITTER: Jia S
PROVIDER: S-EPMC6996876 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20190424 18
Site-selective bioconjugation to native protein residues is a powerful tool for protein functionalization, with cysteine and lysine side chains being the most common points for attachment owing to their high nucleophilicity. We now report a strategy for histidine modification using thiophosphorodichloridate reagents that mimic post-translational histidine phosphorylation, enabling fast and selective labeling of protein histidines under mild conditions where various payloads can be introduced via ...[more]