Ontology highlight
ABSTRACT:
SUBMITTER: Domnina A
PROVIDER: S-EPMC5828181 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Domnina Alisa A Novikova Polina P Obidina Julia J Fridlyanskaya Irina I Alekseenko Larisa L Kozhukharova Irina I Lyublinskaya Olga O Zenin Valeriy V Nikolsky Nikolay N
Stem cell research & therapy 20180226 1
<h4>Background</h4>Asherman's syndrome (AS) is one of the gynecological disorders caused by the destruction of the endometrium. For some cases of AS available surgical methods and hormonal therapy are ineffective. Stem cell transplantation may offer a potential alternative for AS cure.<h4>Methods</h4>Human endometrial mesenchymal stem cells (eMSC) organized in spheroids were transplanted in rats with damaged endometrium modeled on AS. Treatment response was defined as pregnancy outcome and litte ...[more]