Ontology highlight
ABSTRACT:
SUBMITTER: Prentice KJ
PROVIDER: S-EPMC5828468 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Prentice Kacey J KJ Wendell Stacy G SG Liu Ying Y Eversley Judith A JA Salvatore Sonia R SR Mohan Haneesha H Brandt Sydney L SL Adams Andrew C AC Serena Wang X X Wei David D FitzGerald Garret A GA Durham Timothy B TB Hammond Craig D CD Sloop Kyle W KW Skarke Carsten C Schopfer Francisco J FJ Wheeler Michael B MB
EBioMedicine 20171219
Prescription ω-3 fatty acid ethyl ester supplements are commonly used for the treatment of hypertriglyceridemia. However, the metabolic profile and effect of the metabolites formed by these treatments remain unknown. Here we utilized unbiased metabolomics to identify 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) as a significant metabolite of the ω-3-acid ethyl ester prescription Lovaza™ in humans. Administration of CMPF to mice before or after high-fat diet feeding at exposures equiv ...[more]