Dataset Information

Comparison of glycemic control and ?-cell function in new onset T2DM patients with PCOS of metformin and saxagliptin monotherapy or combination treatment.

ABSTRACT:

Background

Impaired insulin activity in women with polycystic ovary syndrome might differ from that seen in type 2 diabetes mellitus without polycystic ovary syndrome. This study was designed to compare the effects of treatment with metformin, saxagliptin, and their combination in newly diagnosed women with type 2 diabetes mellitus and polycystic ovary syndrome in China.

Methods

A total of 75 newly diagnosed patients from Shanghai, China with type 2 diabetes mellitus and polycystic ovary syndrome were included in this randomized, parallel, open-label study. All patients received treatment for 24 weeks with metformin, saxagliptin, or their combination. Patients were allocated to one of three treatment groups by a computer-generated code that facilitated equal patient distribution of 25 patients per group. The primary outcome was a change in glycemic control and ?-cell function.

Results

A total of 63 patients completed the study (n?=?21, for each group). The reduction in hemoglobin A1c was significant in the combination group, compared to the monotherapy groups (saxagliptin vs. combination treatment vs. metformin: -?1.1 vs. -1.3 vs. -1.1%, P?=?0.016), whereas it was comparable between the metformin and saxagliptin groups (P?>?0.05). Saxagliptin, metformin, and the combination treatment significantly reduced the homeostasis model assessment- insulin resistance index and increased the deposition index (P??0.05 for all). In addition, saxagliptin and metformin treatments significantly reduced body mass index and high-sensitivity C-reactive protein levels (P?ConclusionsSaxagliptin and metformin were comparably effective in regulating weight loss, glycemic control, and ?-cell function, improving lipid profiles, and reducing inflammation in newly diagnosed type 2 diabetes mellitus patients with polycystic ovary syndrome.

Trial registration

ChiCTR-IPR-17011120 (retrospectively registered on 2017-04-12).

SUBMITTER: Tao T

PROVIDER: S-EPMC5828487 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Publications

Comparison of glycemic control and β-cell function in new onset T2DM patients with PCOS of metformin and saxagliptin monotherapy or combination treatment.

Tao Tao T Wu Peihong P Wang Yuying Y Liu Wei W

BMC endocrine disorders 20180227 1

<h4>Background</h4>Impaired insulin activity in women with polycystic ovary syndrome might differ from that seen in type 2 diabetes mellitus without polycystic ovary syndrome. This study was designed to compare the effects of treatment with metformin, saxagliptin, and their combination in newly diagnosed women with type 2 diabetes mellitus and polycystic ovary syndrome in China.<h4>Methods</h4>A total of 75 newly diagnosed patients from Shanghai, China with type 2 diabetes mellitus and polycysti ...[more]

PMID: 29482528

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