Ontology highlight
ABSTRACT:
SUBMITTER: Koe CT
PROVIDER: S-EPMC5828666 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
eLife 20180227
A central feature of most stem cells is the ability to self-renew and undergo differentiation via asymmetric division. However, during asymmetric division the role of phosphatidylinositol (PI) lipids and their regulators is not well established. Here, we show that the sole type I PI transfer protein, Vibrator, controls asymmetric division of <i>Drosophila</i>neural stem cells (NSCs) by physically anchoring myosin II regulatory light chain, Sqh, to the NSC cortex. Depletion of <i>vib</i> or disru ...[more]