Ontology highlight
ABSTRACT:
SUBMITTER: Khodaparast L
PROVIDER: S-EPMC5830399 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180228 1
Aggregation is a sequence-specific process, nucleated by short aggregation-prone regions (APRs) that can be exploited to induce aggregation of proteins containing the same APR. Here, we find that most APRs are unique within a proteome, but that a small minority of APRs occur in many proteins. When aggregation is nucleated in bacteria by such frequently occurring APRs, it leads to massive and lethal inclusion body formation containing a large number of proteins. Buildup of bacterial resistance ag ...[more]