Ontology highlight
ABSTRACT:
SUBMITTER: Steinhardt JJ
PROVIDER: S-EPMC5830440 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180228 1
HIV-1 broadly neutralizing antibodies (bNAbs) are being explored as passively administered therapeutic and preventative agents. However, the extensively diversified HIV-1 envelope glycoproteins (Env) rapidly acquire mutations to evade individual bNAbs in monotherapy regimens. The use of a "single" agent to simultaneously target distinct Env epitopes is desirable to overcome viral diversity. Here, we report the use of tandem single-chain variable fragment (ScFv) domains of two bNAbs, specific for ...[more]