Ontology highlight
ABSTRACT:
SUBMITTER: Tienken L
PROVIDER: S-EPMC5830539 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20180228 1
In pretargeted radio-immunotherapy, the gradual administration of a non-radioactive tumor antigen-addressing antibody-construct and the subsequent application of a radioactive labeled, low molecular weight substance enable a highly effective and selective targeting of tumor tissue. We evaluated this concept in prostate stem cell antigen (PSCA)-positive cancers using the antigen-specific, biotinylated single chain antibody scFv(AM1)-P-BAP conjugated with tetrameric neutravidin. To visualize the s ...[more]