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A novel and highly efficient esterification process using triphenylphosphine oxide with oxalyl chloride.

ABSTRACT: Triphenylphosphine oxide (TPPO) and oxalyl chloride ((COCl)2) are used as novel and high-efficiency coupling reagents for the esterification of alcohols with carboxylic acids via the TPPO/(COCl)2 system at room temperature for 1?h. The reaction represents the first TPPO-promoted esterification under mild and neutral conditions with excellent yields. Furthermore, we proposed a plausible mechanism with the help of 31P NMR spectroscopy.

SUBMITTER: Jia M

PROVIDER: S-EPMC5830786 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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A novel and highly efficient esterification process using triphenylphosphine oxide with oxalyl chloride.

Jia Mingzhu M Jiang Lixue L Niu Fanfan F Zhang Yu Y Sun Xiaoling X

Royal Society open science 20180221 2

Triphenylphosphine oxide (TPPO) and oxalyl chloride ((COCl)2) are used as novel and high-efficiency coupling reagents for the esterification of alcohols with carboxylic acids via the TPPO/(COCl)2 system at room temperature for 1 h. The reaction represents the first TPPO-promoted esterification under mild and neutral conditions with excellent yields. Furthermore, we proposed a plausible mechanism with the help of 31P NMR spectroscopy. ...[more]

PMID: 29515897

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