Ontology highlight
ABSTRACT:
SUBMITTER: Miyai T
PROVIDER: S-EPMC5830925 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Miyai Tomohiro T Takano Junichiro J Endo Takaho A TA Kawakami Eiryo E Agata Yasutoshi Y Motomura Yasutaka Y Kubo Masato M Kashima Yukie Y Suzuki Yutaka Y Kawamoto Hiroshi H Ikawa Tomokatsu T
Genes & development 20180101 2
Stem cell fate is orchestrated by core transcription factors (TFs) and epigenetic modifications. Although regulatory genes that control cell type specification are identified, the transcriptional circuit and the cross-talk among regulatory factors during cell fate decisions remain poorly understood. To identify the "time-lapse" TF networks during B-lineage commitment, we used multipotent progenitors harboring a tamoxifen-inducible form of Id3, an in vitro system in which virtually all cells beca ...[more]