Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Rathke A
PROVIDER: S-EPMC5831328 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20180111 3
Outer membrane protein G (OmpG) from Escherichia coli has exhibited pH-dependent gating that can be employed by bacteria to alter the permeability of their outer membranes in response to environmental changes. We developed a computational model, Protein Topology of Zoetic Loops (Pretzel), to investigate the roles of OmpG extracellular loops implicated in gating. The key interactions predicted by our model were verified by single-channel recording data. Our results indicate that the gating equili ...[more]