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Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand.

ABSTRACT: We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block copolymers that provide monovalency, fluorescence and narrow size distribution. The ONP can also guide the deposition of chloroaurate ions allowing gold nanoparticles (AuNPs) to be prepared using the ONPs as templates. The DNA strand on AuNPs is shown to preserve its functions.

SUBMITTER: Xing H

PROVIDER: S-EPMC5831407 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand.

Xing Hang H Bai Yugang Y Bai Yunhao Y Tan Li Huey LH Tao Jing J Pedretti Benjamin B Vincil Gretchen A GA Lu Yi Y Zimmerman Steven C SC

Journal of the American Chemical Society 20170306 10

We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block copolymers that provide monovalency, fluorescence and narrow size distribution. The ONP can also guide the deposition of chloroaurate ions allowing gold nanoparticles (AuNPs) to be prepared using the ONPs as templates. The DNA strand on AuNPs is shown to preserve ...[more]

PMID: 28263067

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