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Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations.

ABSTRACT: A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.

SUBMITTER: Fu J

PROVIDER: S-EPMC6988604 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations.

Fu Jianye J Gu Zhengying Z Liu Yang Y Zhang Jun J Song Hao H Yang Yannan Y Yang Yang Y Noonan Owen O Tang Jie J Yu Chengzhong C

Chemical science 20190919 44

A bottom-up self-assembly approach is developed for the synthesis of <b>ABC</b> type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an <i>in vitro</i> epithelial monolayer model mimicking the human intestinal epithelium. ...[more]

PMID: 32110328

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Project description:[Figure: see text].

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