Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations.
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ABSTRACT:
SUBMITTER: Fu J
PROVIDER: S-EPMC6988604 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations.
Fu Jianye J Gu Zhengying Z Liu Yang Y Zhang Jun J Song Hao H Yang Yannan Y Yang Yang Y Noonan Owen O Tang Jie J Yu Chengzhong C
Chemical science 20190919 44
A bottom-up self-assembly approach is developed for the synthesis of <b>ABC</b> type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an <i>in vitro</i> epithelial monolayer model mimicking the human intestinal epithelium. ...[more]
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