Ontology highlight
ABSTRACT:
SUBMITTER: Lambert M
PROVIDER: S-EPMC5831928 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Lambert Marine M Pépin Geneviève G Peralta-Zaragoza Oscar O Matusiak Raphaël R Ly Sophia S Landry Patricia P Provost Patrick P
Non-coding RNA 20161025 4
The ribonuclease Dicer plays a central role in the microRNA pathway by processing microRNA precursors (pre-microRNAs) into microRNAs, a class of 19- to 24-nucleotide non-coding RNAs that regulate expression of ≈60% of the genes in humans. To gain further insights into the function and regulation of Dicer in human cells, we performed a yeast two-hybrid (Y2HB) screen using human Dicer double-stranded RNA-binding domain (dsRBD) as bait. This approach identified tumor necrosis factor (TNF)-like weak ...[more]