Ontology highlight
ABSTRACT:
SUBMITTER: Tremblay V
PROVIDER: S-EPMC5832440 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Tremblay Véronique V Zhang Pamela P Chaturvedi Chandra-Prakash CP Thornton Janet J Brunzelle Joseph S JS Skiniotis Georgios G Shilatifard Ali A Brand Marjorie M Couture Jean-François JF
Structure (London, England : 1993) 20141120 12
DPY-30 is a subunit of mammalian COMPASS-like complexes (complex of proteins associated with Set1) and regulates global histone H3 Lys-4 trimethylation. Here we report structural evidence showing that the incorporation of DPY-30 into COMPASS-like complexes is mediated by several hydrophobic interactions between an amphipathic α helix located on the C terminus of COMPASS subunit ASH2L and the inner surface of the DPY-30 dimerization/docking (D/D) module. Mutations impairing the interaction betwee ...[more]