Ontology highlight
ABSTRACT:
SUBMITTER: Hsu PL
PROVIDER: S-EPMC6948180 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Hsu Peter L PL Shi Hui H Leonen Calvin C Kang Jianming J Chatterjee Champak C Zheng Ning N
Molecular cell 20191113 5
The COMPASS (complex of proteins associated with Set1) complex represents the prototype of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 methylation (H3K4me). Although H2B monoubiquitination (H2Bub) is well known as a prerequisite histone mark for COMPASS activity, how H2Bub activates COMPASS remains unclear. Here, we report the cryoelectron microscopy (cryo-EM) structures of an extended COMPASS catalytic module (CM) bound to the H2Bub and free nucleosome. Th ...[more]