Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women.

ABSTRACT:

Objective

We evaluated improvement of quality of life (QoL) after 1 year of second-line antiretroviral therapy (ART) use in resource-limited settings (RLS) among adult men and women, comparing two randomized treatment arms.

Design

The AIDS Clinical Trial Group A5273 was a randomized clinical trial of second-line ART comparing lopinavir/ritonavir (LPV/r) + raltegravir with LPV/r + nucleos(t)ide reverse transcriptase inhibitors (NRTIs) in participants failing a non-NRTI-containing regimen at 15 sites in nine RLS. Participants completed the AIDS Clinical Trial Group short-form-21 which has eight QoL domains with a standard score ranging from 0 (worst) to 100 (best).

Methods

Differences in QoL by randomized arm, as well as by demographic and clinical variables, were evalu

SUBMITTER: Torres TS 

PROVIDER: S-EPMC5832593 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature