Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells.
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ABSTRACT:
SUBMITTER: Hong F
PROVIDER: S-EPMC5832973 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
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Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells.
Hong Fei F Wan Lu L Liu Jie J Huang Ke K Xiao Zhenmeng Z Zhang Yingjing Y Shi Chunwei C
FEBS open bio 20180125 3
Liver fibrosis is characterized by deposition of excessive extracellular matrix (ECM). The major source of ECM is activated hepatic stellate cells (HSCs). Previously, we reported that hypoxia-inducible factor-1 (Hif-1) regulates activation of HSCs through autophagy. In current work, human HSC cell line LX-2 was used as cell model. It was determined that trimethylation of H3 histone on lysine 4 (H3K4me3) occurred in the Hif-1 transcriptional complex. Inhibition of modifications of histone methyla ...[more]
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