Dataset Information

MCL-1 is a prognostic indicator and drug target in breast cancer.

ABSTRACT: Analysis of publicly available genomic and gene expression data demonstrates that MCL1 expression is frequently elevated in breast cancer. Distinct from other pro-survival Bcl-2 family members, the short half-life of MCL-1 protein led us to investigate MCL-1 protein expression in a breast cancer tissue microarray and correlate this with clinical data. Here, we report associations between high MCL-1 and poor prognosis in specific subtypes of breast cancer including triple-negative breast cancer, an aggressive form that lacks targeted treatment options. Deletion of MCL-1 in the mammary epithelium of genetically engineered mice revealed an absolute requirement for MCL-1 in breast tumorigenesis. The clinical applicability of these findings was tested through a combination of approaches including knock-down or inhibition of MCL-1 to show triple-negative breast cancer cell line dependence on MCL-1 in vitro and in vivo. Our data demonstrate that high MCL-1 protein expression is associated with poor outcome in breast cancer and support the therapeutic targeting of MCL-1 in this disease.

SUBMITTER: Campbell KJ

PROVIDER: S-EPMC5833338 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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MCL-1 is a prognostic indicator and drug target in breast cancer.

Campbell Kirsteen J KJ Dhayade Sandeep S Ferrari Nicola N Sims Andrew H AH Johnson Emma E Mason Susan M SM Dickson Ashley A Ryan Kevin M KM Kalna Gabriela G Edwards Joanne J Tait Stephen W G SWG Blyth Karen K

Cell death & disease 20180116 2

Analysis of publicly available genomic and gene expression data demonstrates that MCL1 expression is frequently elevated in breast cancer. Distinct from other pro-survival Bcl-2 family members, the short half-life of MCL-1 protein led us to investigate MCL-1 protein expression in a breast cancer tissue microarray and correlate this with clinical data. Here, we report associations between high MCL-1 and poor prognosis in specific subtypes of breast cancer including triple-negative breast cancer, ...[more]

PMID: 29339815

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Dataset Information

MCL-1 is a prognostic indicator and drug target in breast cancer.

Publications

MCL-1 is a prognostic indicator and drug target in breast cancer.

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