Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
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ABSTRACT:
SUBMITTER: Luptak J
PROVIDER: S-EPMC6834078 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Luptak Jakub J Bista Michal M Fisher David D Flavell Liz L Gao Ning N Wickson Kate K Kazmirski Steven L SL Howard Tina T Rawlins Philip B PB Hargreaves David D
Acta crystallographica. Section D, Structural biology 20191031 Pt 11
Apoptosis is a crucial process by which multicellular organisms control tissue growth, removal and inflammation. Disruption of the normal apoptotic function is often observed in cancer, where cell death is avoided by the overexpression of anti-apoptotic proteins of the Bcl-2 (B-cell lymphoma 2) family, including Mcl-1 (myeloid cell leukaemia 1). This makes Mcl-1 a potential target for drug therapy, through which normal apoptosis may be restored by inhibiting the protective function of Mcl-1. Her ...[more]
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