Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Y
PROVIDER: S-EPMC5833342 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Zheng Yan Y Zhou Chuang C Yu Xin-Xin XX Wu Chao C Jia Hu-Liang HL Gao Xiao-Mei XM Yang Ji-Meng JM Wang Chao-Qun CQ Luo Qin Q Zhu Ying Y Zhang Yu Y Wei Jin-Wang JW Sheng Yuan-Yuan YY Dong Qiong-Zhu QZ Qin Lun-Xiu LX
Cell death & disease 20180207 2
The incidence and mortality of intrahepatic cholangiocarcinoma (ICC) are increasing worldwide in recent decades. Osteopontin (OPN) plays an important role in cancer metastasis, but its functional mechanism in ICC is not clear yet. In this study, we found that OPN level was elevated both in plasma and tumor tissues of ICC patients, which was closely related to a shorter overall survival (OS) and high probability of tumor relapse after curative resection. The gain- and loss-of-function studies det ...[more]