Ontology highlight
ABSTRACT:
SUBMITTER: Habiel DM
PROVIDER: S-EPMC5833466 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Habiel David M DM Moreira Ana Paula AP Ismailoglu Ugur B UB Dunleavy Michael P MP Cavassani Karen A KA van Rooijen Nico N Coelho Ana Lucia AL Hogaboam Cory M CM
Mediators of inflammation 20180124
Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease characterized by the persistence of activated myofibroblasts resulting in excessive deposition of extracellular matrix proteins and profound tissue remodeling. In the present study, the expression of tumor necrosis factor- (TNF-) related apoptosis-inducing ligand (TRAIL) was key to the resolution of bleomycin-induced pulmonary fibrosis. Both <i>in vivo</i> and <i>in vitro</i> studies demonstrated that Gr-1<s ...[more]