Ontology highlight
ABSTRACT:
SUBMITTER: Han HS
PROVIDER: S-EPMC5834075 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Han H S HS Diéras V V Robson M M Palácová M M Marcom P K PK Jager A A Bondarenko I I Citrin D D Campone M M Telli M L ML Domchek S M SM Friedlander M M Kaufman B B Garber J E JE Shparyk Y Y Chmielowska E E Jakobsen E H EH Kaklamani V V Gradishar W W Ratajczak C K CK Nickner C C Qin Q Q Qian J J Shepherd S P SP Isakoff S J SJ Puhalla S S
Annals of oncology : official journal of the European Society for Medical Oncology 20180101 1
<h4>Background</h4>Homologous recombination defects in BRCA1/2-mutated tumors result in sensitivity to poly(ADP-ribose) polymerase inhibitors, which interfere with DNA damage repair. Veliparib, a potent poly(ADP-ribose) polymerase inhibitor, enhanced the antitumor activity of platinum agents and temozolomide in early phase clinical trials. This phase II study examined the safety and efficacy of intermittent veliparib with carboplatin/paclitaxel (VCP) or temozolomide (VT) in patients with BRCA1/2 ...[more]