Ontology highlight
ABSTRACT:
SUBMITTER: Baldassari S
PROVIDER: S-EPMC5834504 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Baldassari Sara S Solari Agnese A Zuccari Guendalina G Drava Giuliana G Pastorino Sara S Fucile Carmen C Marini Valeria V Daga Antonio A Pattarozzi Alessandra A Ratto Alessandra A Ferrari Angelo A Mattioli Francesca F Barbieri Federica F Caviglioli Gabriele G Florio Tullio T
Scientific reports 20180302 1
Metformin is an antidiabetic drug which possesses antiproliferative activity in cancer cells when administered at high doses, due to its unfavorable pharmacokinetics. The aim of this work was to develop a pharmacological tool for the release of metformin in proximity of the tumor, allowing high local concentrations, and to demonstrate the in vivo antitumor efficacy after a prolonged metformin exposition. A 1.2% w/w metformin thermoresponsive parenteral formulation based on poloxamers P407 and P1 ...[more]