Ontology highlight
ABSTRACT:
SUBMITTER: Clemente C
PROVIDER: S-EPMC5834547 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Clemente Cristina C Rius Cristina C Alonso-Herranz Laura L Martín-Alonso Mara M Pollán Ángela Á Camafeita Emilio E Martínez Fernando F Mota Rubén A RA Núñez Vanessa V Rodríguez Cristina C Seiki Motoharu M Martínez-González José J Andrés Vicente V Ricote Mercedes M Arroyo Alicia G AG
Nature communications 20180302 1
Matrix metalloproteinases are involved in vascular remodeling. Little is known about their immune regulatory role in atherosclerosis. Here we show that mice deficient for MT4-MMP have increased adherence of macrophages to inflamed peritonea, and larger lipid deposits and macrophage burden in atherosclerotic plaques. We also demonstrate that MT4-MMP deficiency results in higher numbers of patrolling monocytes crawling and adhered to inflamed endothelia, and the accumulation of Mafb+ apoptosis inh ...[more]