Ontology highlight
ABSTRACT:
SUBMITTER: Tsuchiya K
PROVIDER: S-EPMC3736810 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Tsuchiya Kyoichiro K Westerterp Marit M Murphy Andrew J AJ Subramanian Vidya V Ferrante Anthony W AW Tall Alan R AR Accili Domenico D
Circulation research 20130218 7
<h4>Rationale</h4>Increased neutrophil and monocyte counts are often associated with an increased risk of atherosclerosis, but their relationship to insulin sensitivity is unknown.<h4>Objective</h4>To investigate the contribution of forkhead transcription factors (FoxO) in myeloid cells to neutrophil and monocyte counts, atherosclerosis, and systemic insulin sensitivity.<h4>Methods and results</h4>Genetic ablation of the 3 genes encoding FoxO isoforms 1, 3a, and 4, in myeloid cells resulted in a ...[more]