Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5835120 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Liu Yuanyuan Y Fortmann Seth D SD Shen Jikui J Wielechowski Erik E Tretiakova Anna A Yoo Stephen S Kozarsky Karen K Wang Jiangxia J Wilson James M JM Campochiaro Peter A PA
Molecular therapy : the journal of the American Society of Gene Therapy 20171208 2
Sustained suppression of VEGF is needed in many patients with neovascular age-related macular degeneration (NVAMD), and gene transfer of a VEGF-neutralizing protein is a promising approach to achieve it. Initial clinical trials testing this approach have shown encouraging signals, but evidence of robust transgene expression and consistent antiangiogenic and antipermeability activity has been lacking. In this study, we demonstrate expression of an anti-human VEGF antibody fragment (antiVEGFfab) a ...[more]