Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair.

ABSTRACT: Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6Chi at day 1 after BaCl2 injection, while many were Ly6Clo at day 3. Ly6Chi macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6Chi and Ly6Clo macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.

SUBMITTER: Wang X 

PROVIDER: S-EPMC5835410 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature