Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC5835838 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Chen Xing X Zhao Lili L Kang Yang Y He Zhiyu Z Xiong Fei F Ling Xiang X Wu Jun J
Frontiers in pharmacology 20180228
Non-small-cell lung cancer (NSCLC) accounts for over 85% of clinical lung cancer cases, which is the leading cause of cancer-related death. To develop new therapeutic strategy for NSCLC, a library of L-phenylalanine-based poly(ester amide) (Phe-PEA) polymers was synthesized and assembled with docetaxel (Dtxl) to form Dtxl-loaded Phe-PEA nanoparticles (NPs). The hydrophobic Phe-PEA polymers were able to form NPs by nanoprecipitation method and the characterization results showed that the screened ...[more]