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Association between long non-coding RNAs expression and pathogenesis and progression of gliomas.

ABSTRACT: The incidence rate of gliomas is the highest among primary brain tumors. Although the understanding of the molecular pathology of glioma has improved during the previous two decades, effective therapies are not yet available to treat these tumors. Previous studies have indicated that long non-coding RNAs (lncRNAs) have a close association with glioma, suggesting that lncRNAs may be potential targets for the development of novel treatments for glioma. The present review summarized the latest studies on the dysregulation of lncRNAs in glioma, and discussed their potential use in the diagnosis, prognosis and therapies of glioma. The emergence of lncRNAs has revealed an additional facet to glioma oncogenesis. An improved understanding of their functions is important to advance lncRNA-based diagnosis, prognosis and therapeutic interventions of glioma.

SUBMITTER: Zhou J

PROVIDER: S-EPMC5835862 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Association between long non-coding RNAs expression and pathogenesis and progression of gliomas.

Zhou Jie J Xiang Wei W Li Shenjie S Hu Qi Q Peng Tao T Chen Ligang L Ming Yang Y

Oncology letters 20180126 4

The incidence rate of gliomas is the highest among primary brain tumors. Although the understanding of the molecular pathology of glioma has improved during the previous two decades, effective therapies are not yet available to treat these tumors. Previous studies have indicated that long non-coding RNAs (lncRNAs) have a close association with glioma, suggesting that lncRNAs may be potential targets for the development of novel treatments for glioma. The present review summarized the latest stud ...[more]

PMID: 29541171

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