Ontology highlight
ABSTRACT:
SUBMITTER: Quaile AT
PROVIDER: S-EPMC5836138 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Quaile Andrew T AT Stogios Peter J PJ Egorova Olga O Evdokimova Elena E Valleau Dylan D Nocek Boguslaw B Kompella Purnima S PS Peisajovich Sergio S Yakunin Alexander F AF Ensminger Alexander W AW Savchenko Alexei A
The Journal of biological chemistry 20180104 9
Host colonization by Gram-negative pathogens often involves delivery of bacterial proteins called "effectors" into the host cell. The pneumonia-causing pathogen <i>Legionella pneumophila</i> delivers more than 330 effectors into the host cell via its type IVB Dot/Icm secretion system. The collective functions of these proteins are the establishment of a replicative niche from which <i>Legionella</i> can recruit cellular materials to grow while evading lysosomal fusion inhibiting its growth. Usin ...[more]