A macrophage relay for long-distance signaling during postembryonic tissue remodeling.
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ABSTRACT:
SUBMITTER: Eom DS
PROVIDER: S-EPMC5836293 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
A macrophage relay for long-distance signaling during postembryonic tissue remodeling.
Eom Dae Seok DS Parichy David M DM Parichy David M DM
Science (New York, N.Y.) 20170216 6331
Macrophages have diverse functions in immunity as well as in development and homeostasis. We identified a function for these cells in long-distance communication during postembryonic tissue remodeling. Ablation of macrophages in zebrafish prevented melanophores from coalescing into adult pigment stripes. Melanophore organization depends on signals provided by cells of the yellow xanthophore lineage via airinemes, long filamentous projections with vesicles at their tips. We show that airineme ext ...[more]
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