Ontology highlight
ABSTRACT:
SUBMITTER: Zhang T
PROVIDER: S-EPMC5836505 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zhang Tao T Wu Yen-Ching YC Mullane Patrick P Ji Yon Ju YJ Liu Honghe H He Lu L Arora Amit A Hwang Ho-Yon HY Alessi Amelia F AF Niaki Amirhossein G AG Periz Goran G Guo Lin L Wang Hejia H Elkayam Elad E Joshua-Tor Leemor L Myong Sua S Kim John K JK Shorter James J Ong Shao-En SE Leung Anthony K L AKL Wang Jiou J
Molecular cell 20180301 5
MicroRNA-mediated gene silencing is a fundamental mechanism in the regulation of gene expression. It remains unclear how the efficiency of RNA silencing could be influenced by RNA-binding proteins associated with the microRNA-induced silencing complex (miRISC). Here we report that fused in sarcoma (FUS), an RNA-binding protein linked to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), interacts with the core miRISC component AGO2 and is required for optimal microRNA-medi ...[more]