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Mechanistic Insights into MicroRNA-Mediated Gene Silencing.


ABSTRACT: MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein synthesis and exert a broad influence over development, physiology, adaptation, and disease. Over the past two decades, great strides have been made toward elucidating how miRNAs go about shutting down messenger RNA (mRNA) translation and promoting mRNA decay.

SUBMITTER: Duchaine TF 

PROVIDER: S-EPMC6396329 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Mechanistic Insights into MicroRNA-Mediated Gene Silencing.

Duchaine Thomas F TF   Fabian Marc R MR  

Cold Spring Harbor perspectives in biology 20190301 3


MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein synthesis and exert a broad influence over development, physiology, adaptation, and disease. Over the past two decades, great strides have been made toward elucidating how miRNAs go about shutting down messenger RNA (mRNA) translation and promoting mRNA decay. ...[more]

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