Dataset Information

Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens.

ABSTRACT: Human adenoviruses (HAdVs) are uniquely important "model organisms" as they have been used to elucidate fundamental biological processes, are recognized as complex pathogens, and are used as remedies for human health. As pathogens, HAdVs may effect asymptomatic or mild and severe symptomatic disease upon their infection of respiratory, ocular, gastrointestinal, and genitourinary systems. High-resolution genomic data have enhanced the understanding of HAdV epidemiology, with recombination recognized as an important and major pathway in the molecular evolution and genesis of emergent HAdV pathogens. To support this view and to actualize an algorithm for identifying, characterizing, and typing novel HAdVs, we determined the DNA sequence of 95 isolates from archives containing historically important pathogens and collections housing currently circulating strains to be sequenced. Of the 85 samples that were completely sequenced, 18 novel recombinants within species HAdV-B and D were identified. Two HAdV-D genomes were found to contain novel penton base and fiber genes with significant divergence from known molecular types. In this data set, we found additional isolates of HAdV-D53 and HAdV-D58, two novel genotypes recognized recently using genomics. This supports the thesis that novel HAdV genotypes are not limited to "one-time" appearances of the prototype but are of importance in HAdV epidemiology. These data underscore the significance of lateral genomic transfer in HAdV evolution and reinforce the potential public health impact of novel genotypes of HAdVs emerging in the population.

SUBMITTER: Ismail AM

PROVIDER: S-EPMC5837155 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens.

Ismail Ashrafali M AM Cui Tiange T Dommaraju Kalpana K Singh Gurdeep G Dehghan Shoaleh S Seto Jason J Shrivastava Susmita S Fedorova Nadia B NB Gupta Neha N Stockwell Timothy B TB Halpin Rebecca R Madupu Ramana R Heim Albert A Kajon Adriana E AE Romanowski Eric G EG Kowalski Regis P RP Malathi Jambulingam J Therese Kuzhanthai L KL Madhavan Hajib Narahari HN Zhang Qiwei Q Ferreyra Leonardo J LJ Jones Morris S MS Rajaiya Jaya J Dyer David W DW Chodosh James J Seto Donald D

Emerging microbes & infections 20180207 1

Human adenoviruses (HAdVs) are uniquely important "model organisms" as they have been used to elucidate fundamental biological processes, are recognized as complex pathogens, and are used as remedies for human health. As pathogens, HAdVs may effect asymptomatic or mild and severe symptomatic disease upon their infection of respiratory, ocular, gastrointestinal, and genitourinary systems. High-resolution genomic data have enhanced the understanding of HAdV epidemiology, with recombination recogni ...[more]

PMID: 29410402

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Dataset Information

Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens.

Publications

Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens.

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