Biomarkers of lupus nephritis histology and flare: deciphering the relevant amidst the noise.
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ABSTRACT:
SUBMITTER: Birmingham DJ
PROVIDER: S-EPMC5837441 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Biomarkers of lupus nephritis histology and flare: deciphering the relevant amidst the noise.
Birmingham Daniel J DJ Merchant Michael M Waikar Sushrut S SS Nagaraja Haikady H Klein Jon B JB Rovin Brad H BH
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20170101 suppl_1
Biomarker development in lupus nephritis (LN) has traditionally relied on comparing the characteristics of candidate markers to clinical findings in patients and controls from cross-sectional cohorts. In this work, two additional strategies for LN biomarker development that are gaining ground will be discussed. One approach compares analytes directly to kidney histology. The second strategy utilizes longitudinal measurements of biomarker levels at regular intervals as patients move from disease ...[more]
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