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Plasmonic-Based Electrochemical Impedance Imaging of Electrical Activities in Single Cells.

ABSTRACT: Studying electrical activities in cells, such as action potential and its propagation in neurons, requires a sensitive and non-invasive analytical tool that can image local electrical signals with high spatial and temporal resolutions. Here we report a plasmonic-based electrochemical impedance imaging technique to study transient electrical activities in single cells. The technique is based on the conversion of the electrical signal into a plasmonic signal, which is imaged optically without labels. We demonstrate imaging of the fast initiation and propagation of action potential within single neurons, and validate the imaging technique with the traditional patch clamp technique. We anticipate that the plasmonic imaging technique will contribute to the study of electrical activities in various cellular processes.

SUBMITTER: Liu XW

PROVIDER: S-EPMC5837822 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Plasmonic-Based Electrochemical Impedance Imaging of Electrical Activities in Single Cells.

Liu Xian-Wei XW Yang Yunze Y Wang Wei W Wang Shaopeng S Gao Ming M Wu Jie J Tao Nongjian N

Angewandte Chemie (International ed. in English) 20170515 30

Studying electrical activities in cells, such as action potential and its propagation in neurons, requires a sensitive and non-invasive analytical tool that can image local electrical signals with high spatial and temporal resolutions. Here we report a plasmonic-based electrochemical impedance imaging technique to study transient electrical activities in single cells. The technique is based on the conversion of the electrical signal into a plasmonic signal, which is imaged optically without labe ...[more]

PMID: 28504338

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