Ontology highlight
ABSTRACT:
SUBMITTER: Razawy W
PROVIDER: S-EPMC5838536 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Razawy Wida W van Driel Marjolein M Lubberts Erik E
European journal of immunology 20180115 2
The IL-23/Th17 axis has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). RA and PsA are heterogeneous diseases with substantial burden on patients. Increasing evidence suggests that the IL-23 signaling pathway may be involved in the development of autoimmunity and erosive joint damage. IL-23 can act either directly or indirectly on bone forming osteoblasts as well as on bone resorbing osteoclasts. As IL-23 regulates the a ...[more]