Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5839385 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes.
Wang Xiaomei X Malawista Anna A Qian Feng F Ramsey Christine C Allore Heather G HG Montgomery Ruth R RR
Oncotarget 20180103 11
The multifactorial immune deterioration in aging--termed "inflamm-aging"--is comprised of a state of low-grade, chronic inflammation and complex dysregulation of responses to immune stimulation. The TAM family (Tyro 3, Axl, and Mer) of receptor tyrosine kinases are negative regulators of Toll like receptor-mediated immune responses that broadly inhibit cytokine receptor cascades to inhibit inflammation. Here we demonstrate elevated expression of TAM receptors in monocytes of older adults, and an ...[more]
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